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The addition of calcium salts (chloride or carbonate) forms a calcium pectate gel which protects the fruit against softening; these are known as rming agents womens health jensen beach purchase 30caps evecare free shipping. The resultant meal is a valuable source of protein for animal feedingstuff breast cancer games order generic evecare from india, or womens health exercise equipment buy discount evecare on line, after deodorisation menstrual cycle at 8 buy evecare 30caps cheap, as human food since it contains about 70% protein of biological value up to 0. Meal made from white sh is termed white sh meal, distinct from the oily type which is sometimes of very poor quality and is then used as fertiliser. Fish oil concentrates containing these fatty acids are sold as pharmaceutical preparations. A 120g serving is a source of Mg; good source of vitamin B6; rich source of protein, niacin, vitamin B12, I, Se. The food is sterilised at 121°C and then canned at that temperature, not requiring further heat. The process is claimed to give improved taste and texture compared with conventional canning, and the possibility of using large containers without overheating the food. Those identied include small oligosaccharides such as rafnose, stachyose and verbascose in a variety of beans. Economically they are the most important of the thermophilic spoilage agents (thermophiles); some species can grow slowly at 25°C and thus spoil products after long storage periods. It contains the oil sacs, and hence the aromatic oils, and numerous plastids which are green and contain chlorophyll in the unripe fruit, turning yellow or orange in the ripe fruit, when they contain carotene and xanthophyll. They occur as glycosides in which the sugar moiety is usually glucose or rhamnose. At one time a mixture of avonoids was shown to decrease capillary permeability and fragility in human beings and was named vitamin P, but later, 1950, when it was found that they are not dietary essentials, the name was dropped. More recently there has been epidemiological evidence that avonoids may have a role in protection against some forms of cancer from observations in population groups with a high intake of fruits and vegetables. Some are antioxidants and may help to prevent atherosclerosis; others have weak oestrogen activity (phyto-oestrogens). A 120g serving is a source of vitamin B1,B2, B6; good source of I; rich source of protein, niacin, vitamin B12,Se. Used for making cakes, since it is possible to add up to 140 parts sugar to 100 parts of this our, whereas only half this quantity of sugar can be incorporated into ordinary our. The method achieves intimate mixing without mechanical damage; applied to cereals, tableting granules, salt, coffee and dried vegetables. Dutch ummery is made with gelatine or isinglass and egg yolk; Spanish ummery with cream, rice our and cinnamon. Therefore only free antibody will yield the uorescent product when the enzyme is added. Although it occurs in small amounts in plants and animals, and has effects on the formation of dental enamel and bones, it is not considered to be a dietary essential and no deciency signs are known. Drinking water containing about 1 part per million of uoride protects teeth from decay, and in some areas uoride is added to drinking water to achieve this level. Water containing more than about 12ppm uoride can lead to 169 chalky white patches on the surface of the teeth, known as mottled enamel. At higher levels there is strong brown mottling of the teeth and inappropriate deposition of uoride in bones, uorosis. Both the exciting and emitted wavelengths are characteristic of the analyte, and the intensity of uorescence is proportional to the concentration of analyte present. They inltrate the arterial wall and lead to the development of fatty streaks, and eventually atherosclerosis. The liquid concentrate is whipped to a foam with the aid of a foaming agent, spread on a tray and dried in a stream of warm air. It reconstitutes very rapidly with water because of the ne structure of the foam. The liver of goose or duck that has been force fed and fattened; may be cooked whole or used as the basis of pate de foie gras, the most highly prized of the pates. Essential for the synthesis of purines and pyrimidines (and so for nucleic acid synthesis and hence cell division); the principal deciency disease is megaloblastic anaemia, due to failure of the normal maturation of red blood cells, with release into the circulation of immature precursors of red blood cells. Mixed food folate is about 50% as biologically active as synthetic tetrahydrofolic acid used in enrichment and supplements. Supplements of 400mg free folic acid/day begun before conception reduce the incidence of spina bida and other neural tube defects in babies; it is unlikely that ordinary foods could provide this much folate, so supplements are advised. See also dietary folate equivalents;dump suppression test; glu test; homocysteine; methylenetetrahydrofolate reductase. Prepared by boiling sugar solution with the addition of glucose syrup or an inverting agent (see invert sugar) and cooling rapidly while stirring. Fondue bourguignonne is small cubes of marinated meat, cooked on a long fork in a vessel of hot oil at the table. The 171 causative agents may be present in food as a result of infection of animals from which food is prepared or contamination at source or during manufacture, storage and preparation. Three main categories: (1) diseases caused by microorganisms (including parasites) that invade and multiply in the body; (2) diseases caused by toxins produced by microorganisms growing in the gastrointestinal tract; (3) disease caused by the ingestion of food contaminated with poisonous chemicals or containing natural toxins or the toxins produced by microorganisms in the food. Although the analyses are performed with great precision, they are, of necessity, only performed on a few samples of each type of food. There is considerable variation, especially in the content of vitamins and minerals, between different samples of the same food. Therefore, calculation of energy and nutrient intakes based on use of food composition tables, even when intake has been weighed, can only be considered to be accurate to within about ±10%, at best. The protective action of the ingredients of food renders the bacteria more resistant than buffer. The term is used for a cake lling made from eggs, milk and our with avouring, and also for a pastry lled with an almond avoured mixture. The precise 173 levels at which such claims are permitted differ from one country to another. Freeze-dried food is very porous, since it occupies the same volume as the original and so rehydrates rapidly. Controlled heat may be applied to the process without melting the frozen material, this is accelerated freeze drying. A freezing compartment of a refrigerator (for short-term storage of frozen foods) is between -11°C (12°F), two star (**) rated, for storage up to four weeks and -4°C (25°F), one star (*) rated, for storage up to a week. A three star (***) deep freeze with a snowake symbol is one that is suitable for freezing foods, as opposed to storing readyfrozen food; it has a higher cooling capacity than a simple storage cabinet. A 45g serving (one tablespoon) is a source of vitamin B2; rich source of vitamin B12. Found as the free sugar in fruits and honey, and as a constituent of the disaccharide sucrose. Deep frying, in which a food is completely covered with oil, reaches a temperature around 185°C. Nutrient losses are less than in roasting, about 10–20% thiamin, 10–15% riboavin and nicotinic acid from meat; about 20% thiamin from sh. Microfungi are moulds, as opposed to larger fungi, which are mushrooms and toadstools. Species of moulds such as Penicillium, Aspergillus, etc are important causes of food spoilage in the presence of oxygen and relatively high humidity. A number of larger fungi (mushrooms) are cultivated, and other wild species are harvested for their delicate avour. The mycelium of smaller fungi (including Graphium, Fusarium and Rhizopus species) are grown commercially on waste carbohy176 drate as a rich source of protein (mycoprotein) for food manufacture. Present in low concentration in wines and beer, and high concentration in pot-still spirit. On maturation of the liquor fusel oil changes and imparts the special avour to the spirit. Many of the symptoms of hangover can be attributed to fusel oil in alcoholic beverages. F value A unit of measurement used to compare relative sterilising effects of different procedures (total time–temperature combination); equal to 1min at 121. G gaffelbitar Semi-preserved herring in which microbial growth is checked by the addition of 10–12% salt and sometimes benzoic acid.

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The second application of Markovian Analysis is also related to breast cancer uggs boots purchase 30 caps evecare mastercard the fixed point of Pn breast cancer 4 stage purchase genuine evecare online, since directly provides the long run equilibrium of the system (Kemeny and Snell breast cancer 6s jordans buy evecare with a mastercard, 1972 breast cancer medication discount evecare 30caps mastercard, p. This equilibrium may be interpreted as the long run (percent) distribution of units between states, since system transitions between states are defined as counts of units’ transitions. Results: description and discussion In this section findings are presented relating to the selected academic libraries. Comments follow the order of proposed steps – computed efficiency scores, operation plans and long run distribution. Accordingly, the coefficients of variation imply that the libraries are quite different from one another on most attributes. Note that some inefficient libraries never visited the efficient frontier and are even far away of it; in that sense they also deserve managerial attention. Note also that library number 5 has been efficient along the whole period except for one year. In terms of management action all these signals must likely be accompanied by an individual follow-up. Second step: optimal changes for each library along the period Operation plans are summarized in Table 4 and deserve managerial attention since resource decreases may occur simultaneously with output increases, so that managers must keep alert and proactive as to take advantage from potential efficiency gains along time. Volume discards deserve special attention because some collections and some individual titles should not be altered. This means that if a given unit is inefficient today and if no managerial action is taken, then on average it will take 22 months for the unit to become efficient. This delay may be compared to the time required for any possible remedial measures to become effective, say revised budgeting or training. Inputs 2000 2001 2002 2003 2004 2005 2006 2007 Employees 1,44 1,15 0,76 1,29 0,93 1,18 0,61 0,81 (number) Area (m2) 60,75 71,04 * 29,85 70,35 48,94 143,47 88,05 136,27 Volumes 3064,48 3373,49 1880,71 4601,0 6447,08 651,77 4720,75 3153,65 (number) Table 4: Average operation plans : 2000 – 2007 Note * – this figure relates to a single library. Note that E, the percent efficient, differs from the mean and the median percent efficient (48,7%) in the last line of Table 3. Remember that, in contrast to “short run averaging”, products of transition matrices bring into play all the transitory visits to the two states along the time span. The fixed point in the equation A = also provides directly the mean recurrence time (Kemeny et al. The mean recurrence time is approximately equal to 2 years in both cases, so that the period of two years seems to be critical in the sense of monitoring the return of a state to itself. In the case of inefficiency it represents a sort of “safe mean time span” for managers to try to change the operating conditions facing inefficient units. Note that on average an inefficient unit will return to inefficiency four months before it may reach efficiency for the first time, if no managerial action is taken. We first computed an aggregate measure of the distribution of the productive system (the “organization”) between two states – efficient or inefficient. The other useful application of the Markovian approach provides better knowledge concerning the time delay required for efficiency to be attained for the first time when a prescribed operation plan happens to be adopted, as well as about the time during which an undesired (inefficient) situation will persist if that adoption is postponed. This timing aspect may help library managers in preparing their planning and control schedules and figures with a view toward the efficiency endeavour. For example, an inefficient unit will on average return to inefficiency four months before it attains efficiency for the first time, so that managerial attention to such time lags may become critical. Future research is likely to provide better theoretical as well as empirical information that will allow for a better assessment of the proposed model. In particular, since the long run is here depicted in a very simple way, the “short memory” assumption involved in Markovian approaches may appear inappropriate in many contexts. This paper describes some current initiatives to address these issues and to respond to emerging requirements in a period of financial constraint and a changing academic landscape. It emphasises the value of community collaboration and support to deliver a responsive service that is effective in meeting the needs of its users. Funded by Jisc as one of the digital content services included in its subscription service, it has four partners, Mimas at the University of Manchester, Cranfield University, Jisc Collections, and Evidence Base at Birmingham City University. This includes supporting provision of digital content for education, analysis of publisher deals, community engagement, technical development, training and support, and project management. This is a machine-to-machine protocol that automates the process of data gathering on behalf of participating libraries. This quick and convenient access to data enables libraries to spend less time on manually gathering data and more time on the important tasks of data analysis, evaluating resources and decision-making. The team also works closely with publishers who recognise the benefits and increased efficiencies that the portal can offer to their customers. The helpdesk aims to provide a quick response to individual queries wherever possible. In addition to support materials available from the website, a community area has been set up within the portal itself, where libraries can share ideas, training materials and presentations that they have used within their own institutions. The team is also working with complementary projects and services to share knowledge and data and by working together aims to deliver greater efficiencies for the community. The primary aim of this co-operation is to ensure that the two services are integrated to the extent that libraries avoid any duplication of effort. A number of technical challenges needed to be overcome in order to create a working demonstrator site which was developed and tested with the aid of a small number of tester libraries. While this proof of concept project was able to demonstrate the technical feasibility of combining these two disparate data sets, it still left many issues unresolved. It is hoped that the search for a means of combining authentication and usage data will continue and that a satisfactory solution can one day be found. Usage profiling Libraries have long been interested in comparing their own usage of e-resources with others of similar size or type. In looking at their own usage figures, libraries will be asking themselves these questions: l How well are we doing Initially, usage profiling is available for three publishers, but it is expected to be extended further, subject always to publisher agreements. The reports show the number of institutions in the particular band or group that take either subscribed titles or a deal with the selected publisher but do not attempt to sort the institutions by the particular deal or collection they take. Visual indicators show whether the library’s usage is above or below average for each band/group. Particular comments received suggested the following ways the reports could be used: l to use when comparing budgets in other institutions with actual usage l to monitor effect of promotional campaigns l to view trends across years l to help provide context for what constitutes ‘good usage’ l to analyse reasons for usage that was higher or lower than average. By supporting the usage profiling reports, publishers are assisting libraries in analysing the value of their e-journal collections and responding to interest in this facility from their customers. Libraries are increasingly being asked to provide information on the value for money and return on investment for e-book collections for instance. However, finding the time and resource to systematically collect and aggregate this information is difficult for libraries. While this trial has been limited to a small number of publishers who had their own e-book collections, it has already identified several issues that would need to be addressed. A further stage would require investigation of the feasibility of including data from e-book platforms, and the types of report that libraries would wish to see. In this way, the various issues that might arise could be explored in more detail. This is a new service that aims to offer training, advice and consultancy to help organisations in managing usage data for e-resources. In: Proceedings of the 8th Northumbria International Conference on Performance Measurement in Libraries and Information Services. Her research interests include the application of business management concepts to library and information services, collection development in the digital world, and the evolving roles and competencies of librarians and information specialists. Abstract Purpose the strategic contribution of subject librarians as information specialists in the digital world has been questioned by institutional administrators, but others have identified expanded roles and new opportunities in learning and research support. The present study investigates the application of Kaplan and Norton’s strategic management system of balanced scorecards and strategy maps to subject librarianship in universities, with particular reference to the intellectual capital represented and created in the structures, relationships, and know-how of liaison work. Data were analyzed thematically to develop an exemplar map and assess its potential for evaluating the contribution of subject librarians. Preliminary results suggest that strategy maps can be used to illustrate the strategic contribution of subject librarians. Research limitations/implications the paper reports the early stages of a multi-phase project. The next phase will explore the development of both maps and balanced scorecards via case studies in different countries. Originality/value: There are few examples of library applications of strategy maps and balanced scorecards at unit or program level, and none with a focus on the intangible assets of subject librarians. Subject liaison librarians have traditionally formed a significant proportion of the professional staff in an academic library (Pinfield, 2001), thus representing a substantial financial commitment by the institution, and the expectations of the role within and beyond the library are being ramped up in response to challenges in the changing higher education environment.

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Chicken salad was implicated in an outbreak in the United States of America and may have been contaminated by a food worker who also operated a daycare facility menstruation 6 days early buy cheap evecare 30 caps line. Numerous surveys performed worldwide have reported the presence of Cryptospo­ ridium oocysts on a wide variety of fresh produce items (Dixon et al women's health clinic fayetteville ar order evecare overnight. Cryp­ tosporidium oocysts have also been reported worldwide in the gills and tissues of oysters and other molluscan shellfsh menstrual cramps 8 months pregnant purchase evecare now, including clams pregnancy myths best 30caps evecare, cockles and mussels (Fayer, Dubey and Lindsay, 2004). At the consumer level, good hygiene and avoidance of crosscontamination are again important control measures. Torough washing of fresh produce is recommended, but probably will not be fully efective in removing all contaminating oocysts. Although oocysts are somewhat resistant to freezing, they can be inactivated by storing produce at -20°C for >24 hours, or at -15°C for at least a week. Alternatively, oocysts will be readily destroyed in foods that are subsequently cooked. Geographical distribution In recent years, human infection with Cryptosporidium spp. Prevalence, however, is very difcult to determine as data is not available from many countries. In one estimate, the prevalence of Cryptosporidium in patients with gastroenteritis was 1–4% in Europe and North America, and 3–20% in Africa, Asia, Australia, and South and Central America (Current and Garcia, 1991). Laberge and Grifths (1996) estimated that the prevalence rates based on oocyst excretion were 1–3% in industrialized countries, and up to 10% in developing countries. Approximately twelve species of Cryptosporidium, and several genotypes, have been reported in humans. Several other Cryptosporidium species and genotypes are only occasionally found in humans (Xiao, 2010). The disease is characterized by watery diarrhoea and a variety of other symptoms, including, abdominal pain, weight loss, nausea, vomiting, fever and malaise (Chalmers and Davies, 2010). Symptoms in some immunocompromised patients become chronic, debilitating and potentially life-threatening. Cryptosporidiosis accounts for up to 6% of all reported diarrhoeal illnesses in immunocompetent persons (Chen et al. In addition to the patients’ immune status, there is some evidence that clinical manifestations of cryptosporidiosis may also be partially dependent upon the species of Crypto­ sporidium involved in the infection. With the exception of Nitazoxanide, which is approved in the United States of America for treating diarrhoea caused by Crypto­ sporidium in immunocompetent patients, drug development has been largely unsuccessful against cryptosporidiosis. Trade relevance Tere have not yet been signifcant trade issues with respect to the fnding of Cryptosporidium oocysts in foods, but with the increasing number of surveillance studies reporting positive results in a wide variety of foods worldwide, and the growing number of produce-associated illness outbreaks, more trade issues resulting in import restrictions and recalls may occur in the future. As has already been seen with respect to Cyclospora cayetanensis in fresh berries, these actions could have signifcant impacts on the agricultural industry and the economy of developing countries that produce and export fresh produce. Diseases included in this initiative “occur mainly in developing countries where climate, poverty and lack of access to services infuence outcomes”, and where they “impair the ability of those infected to achieve their full potential, both developmentally and socio-economically” (Savioli, Smith and Tompson, 2006). As such, cryptosporidiosis in particular may have considerable negative impacts on economically vulnerable populations. Cryptosporidium species and subtypes and clinical manifestations in children, Peru. Sporadic human cryptosporidiosis caused by Cryptosporidium cuniculus, United Kingdom, 2007–2008. Detection of Cyclospo­ ra, Cryptosporidium and Giardia in ready-to-eat packaged leafy greens in Ontario. Sporulated oocysts excyst in the gastrointestinal tract and invade the epithelial cells of the small intestine, where asexual and sexual multiplication occurs. Unsporulated oocysts are formed and excreted in the faeces of the infected individual. It takes 7–15 days under ideal environmental conditions for these oocysts to sporulate and become infectious. A few reports described Cyclospora oocysts in the faeces of dogs, ducks and chickens, but unsuccessful experimental infections and lack of histopathological evidence of infection do not support the availability of an intermediate or defnitive host other than human (Ortega and Sanchez, 2010) and these undoubtedly represented spurious passage of oocysts. In the past decade, other Cyclospora species have been described in non-human primates, but molecular information has confrmed that these species are not C. To date, no deaths have been reported due to Cyclospora infections and there is no evidence that Cyclospora is endemic in the United States of America. Oocysts have been identifed in water used for human consumption in various studies; however, foodborne transmission has been reported more frequently and has been linked to lettuce, basil, snow peas and berries (blackberries and raspberries) (Shields and Olson, 2003) that were consumed raw, and frequently associated with social events. In 1996, 1465 cases of cyclosporiasis, associated with consumption of Guatemalan raspberries, were reported in the United States of America and Canada. In 1997, 1012 more cases were reported associated with the consumption of Guatemalan raspberries, and 342 cases implicated contaminated basil. In 1998, raspberry importations were not permitted into the United States of America whereas importation into Canada continued. Tat year, 315 cases of cyclosporiasis were reported in Canada, again implicating raspberries imported from Guatemala (Herwaldt, 2000). Since then, Cyclospora cases have been reported in the United States of America every year, and in most instances no specifc food commodity has been associated with those outbreaks. In most instances, reports from Europe describe cases associated with travel to endemic areas (Cann et al. The food items implicated as a result of the epidemiological investigation (butterhead lettuce (from Southern France), mixed lettuce (from Bari, Italy), and chives (from Germany)) were not available for microbiological examination (Doller et al. Geographical distribution Cyclospora has been reported to be endemic in China, Cuba, Guatemala, Haiti, India, Mexico, Nepal, Peru and Turkey. Other reports from travellers suggest that Cyclospora could also be endemic in other tropical regions, including Bali, Dominican Republic, Honduras, Indonesia, Papua New Guinea and Tailand (Ortega and Sanchez, 2010). The prevalence of Cyclospora in these regions has changed as the socio-economic conditions of the populations have changed. Tere are reports of infection in parts of Africa, but the absence of infection has been noted in many studies that looked specifcally for it, and further study and confrmation of the distribution of the organisms in this part of the world is required. Disease Cyclosporiasis is characterized by watery diarrhoea, nausea, abdominal pain and anorexia. Biliary disease, Guillain-Barre Syndrome and Reiter’s Syndrome have been reported to follow Cyclospora infections (Ortega and Sanchez, 2010). The severity of illness is higher in children, the elderly, and immunocompromised individuals. Illness usually lasts 7–15 days, but in immunocompromised and a few immunocompetent individuals it can last up to 3 months (Bern et al. The drug of choice to control infection is trimethoprim sulfamethoxazole, but in patients who are allergic to sulfa, ciprofoxacin has been used as an alternative treatment. If not treated, the host’s immune response should eventually control the infection (Pape et al. In endemic areas, children under 10 years frequently acquire the infection, and as they grow and have repeated exposures, infections can be less symptomatic and of shorter duration (Bern et al. The environmental conditions that favour Cyclospora endemicity are not fully elucidated, nor are the conditions that allow for a marked seasonality characteristic in locations where Cyclospora is endemic (Lopez et al. This was very evident during the 1995–1997 outbreaks in the United States of America. Importation of berries (Herwaldt, 2000), particularly raspberries, was afected, causing signifcant fnancial losses to the producers, exporters and importers. In 1996, United States of America strawberry growers were afected as it was assumed that cases of cyclosporiasis were linked with California strawberries. Later it was determined that these outbreaks were associated with the consumption of imported Guatemalan raspberries (Herwaldt et al. In 1996, before the Cyclospora outbreaks occurred, the number of raspberry growers in Guatemala was estimated to be 85. For many growers the decision to leave the industry was based on losses due to the lack of foreign demand of their berries and export markets closures (Calvin, Flores and Foster, 2003). The losses resulting from these outbreaks were signifcant not only fnancially but also for the reputation of the Guatemalan berry industry and the communities involved. The global burden and prevalence of this parasite worldwide need to be considered. Its efect in global trade has been notorious in commodities imported from endemic areas. However, efects on the economy and health of the population in endemic countries, where exports are not an element of consideration in terms of outbreaks in developed countries, need to be further studied. The contrasting epidemiology of Cyclospora and Cryptosporidium among outpatients in Guatemala.

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Detection of antigens Immunocytology (swab material) with the direct immunofluorescence test 6272 menopause evecare 30 caps free shipping, enzyme immunoassay menstrual after menopause buy cheap evecare 30caps. Note: under some conditions false positive results for antigen in stool menopause xanax cheap 30caps evecare fast delivery, check positive results perhaps with complement fixation reaction; serotype identification with the neutralization test breast cancer xmas cards generic 30caps evecare with mastercard, haemagglutination inhibition test; Detection of antibodies From week 2 of the illness, confirmation of the diagnosis by taking 2 blood samples 14 days apart: group specific antigens with complement fixation reaction, typespecificity with haemagglutination inhibition test, IgM/IgG enzyme immunoassay. After exposure Medicinal therapy: specific therapy not available (antiviral substances are being tested); otherwise treatment according to symptoms. Occupational Production and use of fungal cultures (moulds) (special laboratories), reference centres, consulting laboratories, handling animals, plants or other biological products which are colonized, infected or contaminated; regular contact with infected samples or samples suspected of being infected or with contaminated pathogen-containing objects or materials, or materials which release fungal elements. Epstein-Barr virus, cytomegaly virus); contact infection via injured skin or burns, on contact with ornamental and pet birds; endogenous infection (controversial) in persons with persistent immunodeficiency and concomitant pathological colonization (rare) by allochthonous fungal material; other factors predisposing to infection: incompetent immune system, diabetes mellitus, long-term wide-spectrum antibiotic therapy, mucoviscidosis, lack of immunity. Other organ involvement After initial colonization of the lungs, haematogenic dissemination or dissemination per continuitatem in predisposed persons: encephalon/meninges: colonization after advanced dissemination or via the nasopharynx, paranasal sinuses, eye sockets, ears; encephalitis (base of brain), meningoencephalitis; paranasal sinuses: maxillary sinusitis; eyes: especially postoperatively in the form of endophthalmitis, chorioretinitis; keratoconjunctivitis (wearers of contact lenses) with involvement of the tear ducts, colonization of the eye socket from the paranasal sinus with destruction of adjacent bony structures; ears: otomycosis as secondary infection of the external auditory canal, more frequently with A. After exposure In infected persons, operate on localized processes; for the allergic bronchopulmonary form glucocorticoids, anti-asthmatics, mucolytics; for the invasive bronchopulmonary form and dissemination standard parenteral systemic antimycotic therapy. G 42 Activities with a risk of infection 407 7 Additional notes Any national notification regulations are to be observed. Occupational Research institutes, laboratories (regular work and contact with infected animals/ samples, samples and animals suspected of being infected, other contaminated objects or materials containing the infectious agent, given a practicable route of transmission), veterinary medicine, farming, forestry, hunting, firms and industries processing animal material including transport, work in areas where the disease is endemic. Inhalation anthrax: incubation period up to 5 days (depending on the infection dose), initially symptoms of an acute airway infection; then (within 2–4 days) fulminant syndrome: sepsis and/or meningitis, atypical bronchopneumonia with pulmonary necrosis; haemorrhagic thoracic lymphadenitis/mediastinitis; shock symptoms; untreated fatal within 3–5 days. Intestinal anthrax: incubation period a few days, raised temperature, dramatic haemorrhagic gastroenteritis with haematemesis, bloody serous diarrhoea, peritonitis (ascites); prognosis unfavourable. Gram stain, direct immunofluorescence test (capsule) and/or isolation of the pathogen from swab material, sputum, stool, blood. After exposure Isolation of exposed/infected persons generally not necessary; antibiotic therapy in cases of local cutaneous anthrax: ciprofloxacin and penicillin V (7 days); surgical G 42 Activities with a risk of infection 409 procedures contraindicated; in all forms of systemic infections also doxycycline (60 days); when applied in the early phase: fatalities approach 0 % (cutaneous anthrax), 50 % (inhalation anthrax, intestinal anthrax); if the pathogen has been disseminated intentionally. Occupational Facilities for medical examination, treatment and nursing of children and for care of preschool children, care of pregnant women, obstetrics, research institutes, consulting laboratories. Catarrhal stage Duration 1–2 weeks, prodromal influenza-like symptoms with subfebrile temperatures. Stadium decrementi Duration 6–10 weeks, gradual decrease in coughing attacks; intercurrent respiratory infections can cause a recurrence of clinical symptoms. Complications Mainly in the first year of life; about 25 % bacterial aspiration pneumonia, responsible for half of the deaths, secondary infections (H. Borrelia burgdorferi, Borrelia burgdorferi sensu lato 1 Infectious agent Flexible Gram-negative spirochaete, sensitive to environmental factors; complex of human pathogens in Europe includes the species Borrelia (B. Occupational Farming, forestry and timber industry, gardening, kindergartens in the woods, research institutes, reference centres, regular work in low vegetation and in woods. Stadium I: typical erythema (chronicum) migrans, in 40 %–60 % of infected persons; initial papules, then sharply delimited, painless erythema with a pale centre and centrifugal spread, sometimes associated with general influenza-like symptoms (arthralgia, swollen lymph nodes, sometimes a stiff neck); lymphadenosis cutis benigna Bafverstedt (Borrelia lymphocytoma): circumscribed soft, livid reddish tumour covered by thinned skin, sometimes ulcerous and disintegrating (lobes of the ears, mamilla, scrotum). Note: one in two cases with erythema migrans is seronegative; reliable IgM antibody detection; IgG antibodies persist for years after infection (70 %–100 %), also after inapparent infection (10 % of the general population), serological tests should nonetheless be carried out; persistence also after successful therapy; false positive reactions. After exposure After spending time in a tick-infested area, carefully search the body for ticks; remove ticks; disinfect wounds; after a tick bite recommended medicinal therapy with tetracycline. After exposure In case of an infection, medicinal therapy (antibiogram): doxycycline combined with streptomycin or rifampicin; alternatively co-trimoxazole with rifampicin. Burkholderia pseudomallei (Pseudomonas pseudomallei) 1 Infectious agent Burkholderia (B. Occupational Research institutes, laboratories, the health service, veterinary medicine (veterinary practices), farming, zoological gardens, work in areas where the pathogen is endemic. Incubation period depends on the pathogen level: 2–21 days after skin injury, decades after inapparent infections; contagious as long as the pathogen is excreted, transmission from person to person possible (rare); pulmonary form: acute course (75 %) with raised temperature, pneumonia, sometimes lung abscesses, pleural empyema; localized form: multiple abscesses/ulcers with lymphadenitis; chronic form: multiple abscess formation in visceral organs, skin, skeletal muscles, bones; sepsis: fatal in about 50 % of cases, pulmonary form may develop concomitantly. G 42 Activities with a risk of infection 417 6 Specific medical advice Before exposure Exposure prophylaxis: in areas where the pathogen is endemic, close contact with surface water should be avoided, especially by persons with skin injuries; Disposition prophylaxis (vaccination) not available. After exposure If clinically indicated for persons who have spent time in areas where the pathogen is endemic, even decades later (travel anamnesis! Occupational the health and social services, hydrotherapy, balneotherapy, microbiological laboratories, reference centres, veterinary medicine, animal breeding, soil disinfection, sewage works, recycling industry. Surface candidiasis (most common form) Oral mucosa “thrush”: focal whitish removable deposits on reddened tissue, stomatitis, candida leukoplakia, glossitis, angular cheilitis; Body flexurae: favoured by hyperhidrosis, obesity, diabetes mellitus, weeping itching foci (intertrigo), skin between toes and fingers with macerations, whitish scales; Skin appendages: inflammation of the nail folds (paronychia), brittle discoloured nail plates (onychomycosis). G 42 Activities with a risk of infection 419 Chronic mucocutaneous candidiasis Caused by hereditary immune defect with autosomal recessive inheritance: persistent foci and granulomas (mouth, skin, nails, airways), largely resistant to treatment. Gram-stain); culture: macroculture on special media, germ tube test as rapid test (C. Austria, Switzerland, Alsace, some Eastern European, Scandinavian and Balkan countries; natural habitats (ticks) along the edges of woods, wooded river valleys; seasonal from April until November; worldwide about 10000 cases annually, in Germany 255 reported cases (in the year 2001); pathogen reservoir in animals living in the wild (squirrel, lizard, yellownecked mouse (Apodemus flavicollis), bat, fox, hare, mouse, hedgehog, mole, roedeer, red deer, wild pig, birds); domesticated animals (dog, horse, sheep, goat); in animals the disease is very rarely clinically manifest. Occupational In areas in which the organism is endemic: farming, forestry, timber industry, gardening, animal dealing, hunting, research institutes, reference centres, laboratories, consulting laboratories, regular work in low vegetation and in woods, work involving frequent direct contact with wild animals. After exposure Searching the body for ticks: immediate mechanical removal (do not twist! G 42 Activities with a risk of infection 423 Chlamydophila pneumoniae, Chlamydophila psittaci (avian strains) 1 Infectious agent Chlamydia species a) C. Occupational Research institutes, laboratories, consulting laboratories, risk of ornithosis/psittacosis in poultry farming and the poultry processing industry, animal-keeping and veterinary medicine; C. After exposure In infected persons (trachoma) local medicinal therapy, isolation of patients with C. G 42 Activities with a risk of infection 425 Clostridium tetani 1 Infectious agent Clostridium (C. Occupational Work where injuries are common and where wounds may come into contact with soil, road dust, wood, dung, wounds made with contaminated objects; contact with animals. Localized tetanus Rare, mild, abortive form; in partially immune persons manifestations restricted to muscles around the point of entry; only muscle stiffness, no spasms; good prognosis, mostly on the head (cephalic tetanus) after tooth extraction, otitis media; fatal in 1% of cases. Detection of infectious agent Mouse-protection study: excised wound material (30 min. Detection of antibodies To establish the vaccination status/susceptibility to infection: anamnesis of illnesses and vaccinations is not sufficient, inspection of vaccination documents required; serological anti-toxin detection is possible to prevent unnecessary revaccination. Disposition prophylaxis (vaccination) with tetanus toxoid as standard vaccine: one dose of vaccine at ages 2, 3, 4 and 11–14 months, booster at age 5–6 and 9–17 years; with polyvalent combination vaccine; vaccination status must be tested at age 15–23 months, no sure protection from infection if the IgG antitoxin level is 0. Surgical cleansing of the infected area, antibiotic application according to the antibiogram, generally penicillin G, tetracycline (super-infection); metronidazole reduces amount of circulating toxin. Limited possibilities for symptomatic treatment: intensive care for maintenance of vital functions, muscle relaxants (curare-type medication), keeping the airways open (if necessary tracheotomy), long-term artificial ventilation; no particular anti-epidemic measures necessary for persons with the disease or contact persons. G 42 Activities with a risk of infection 429 Localized forms (tonsillo-naso-pharyngeal) Characteristic lesion: pseudomembranous deposits (extensive greyish whitish fibrin exudate), firmly attached, removable only by force and with bleeding. Pharyngeal diphtheria: severe pharyngitis with pseudomembrane formation, often spreads to the tonsils (tonsillitis), palate and uvula, indistinct speech, typical sweetsmelling breath, painful swelling of the cervical lymph nodes; bleeding into the pseudomembrane because of toxic vessel damage, sometimes progressive oedema (“bull neck”). Nasal diphtheria: sanguineous-serous unilateral or bilateral nasal discharge, encrustations (mainly in babies and infants). G 42 Unusual localizations: conjunctiva, vulva, umbilical cord; skin/wounds (typical of tropical countries). Laryngeal diphtheria (progressive form): hoarseness, barking cough, obstruction, inspiratory stridor (“diphtheritic croup”); descent of the pseudomembrane into the trachea and bronchi is possible; respiratory insufficiency with risk of asphyxia. Post-infection toxin-induced complications Cardiotoxicity: myocarditis (conduction system disorders and dysrhythmia), early deaths (week 1), late deaths (after about 6 weeks during convalescence); Neurotoxicity: polyneuritis (n. Detection of antibodies To establish the vaccination status/susceptibility to infection: anamnesis of illnesses and vaccinations is not sufficient, inspection of vaccination documents required; demonstration of anti-diphtheria toxin antibodies in neutralization test. After exposure Isolation of infected persons; given clinical indications immediate administration of diphtheria antitoxin; available at present only from international apothecaries; never wait for the microbiological laboratory results; medicinal prophylaxis independent of vaccination status. Occupational Farming, forestry, timber industry, gardening, animal dealers, the health service, reference centres, consulting laboratories, geriatric centres, body and beauty care (cosmetic salons), hairdressing, centres for medical examinations, treatment and nursing of children, care of pre-school children and young persons, and other communal facilities. G 42 3 Transmission route, immunity Pathogens with affinity for the skin (horny layer) and its appendages (hair, hair follicles, nails); transmission by direct contact with animals or indirectly via contaminated objects, soil or vectors such as arachnids (mites), insects (nits, fleas, flies); hair follicles, dermal (micro-)lesions as entry points, favoured by alkaline skin pH/insufficient evaporation from the skin, increased sweating; no immunity but immune response in the form of a skin reaction of delayed type. Detection of antibodies No serological methods for local mycosis in skin compartments, cutaneous test with group-specific antigens (trichophytin test) of no use in practice. G 42 Activities with a risk of infection 433 G 42 other zoo animals goat game pig sheep cattle rat horse animals bred for fur poultry guinea pig mouse cat rabbit hedgehog dog golden hamster monkey man 434 Guidelines for Occupational Medical Examinations 6 Specific medical advice Before exposure Exposure prophylaxis: personal protective measures (protective clothing which covers the body) when handling animals (see table), especially if they have skin disorders; hygiene and pest control in buildings used for keeping animals; disinfection with fungicidal preparations, control of milieu factors (hyperhidrosis); Disposition prophylaxis (vaccination) not available. After exposure For infected persons antimycotic therapy, topical (skin cream, nail varnish, lotion, spray, powder) and/or systemic with orally administered antibiotics with antimycotic activity. G 42 Activities with a risk of infection 435 3 Transmission route, immunity Transmission from monkey to man, otherwise very readily from person to person given close contact; aerogenic via infectious faecal particles in dust; also via contaminated objects, nosocomial and laboratory infections are possible; in survivors immunity persists probably for life. Specific hygienic measures during nursing and handling the pathogen laid down by specialists; when handling the pathogen intentionally maximum safety precautions (laboratories).

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Clinician will use Mirror Retraining: patients learn to breast cancer oakley sunglasses order evecare 30caps overnight delivery pay attention to women's health clinic dc buy evecare 30 caps without prescription their appearance in a new breast cancer medication buy generic evecare 30 caps online, nonjudgmental way women's health center of edmonton cheap 30caps evecare, learning to give neutral and positive feedback 6. Eliminate pattern of alternating between thinking about and avoiding thinking about the trauma 5. Anxiety management training (breathing relaxation, progressive muscle relaxation, visualization, thoughtstopping, distraction) 4. Cognitive restructuring: over-generalization, all or nothing thinking, and personalization 6. Coping with life problems: living situation, physical health, substance dependence 7. Reduce intrusive symptoms (involuntary distressing memories, distressing dreams, and flashbacks) 6. Clinician will examine the person’s overall capacity to cope with memories of traumatic event(s) and their triggers and the coping style they use to manage these memories 2-Clinician will focus on the effect of traumatic experience on the individual’s prior self-object experiences, overwhelmed self-esteem, altered experience of safety, and loss of self-cohesiveness and self-observing functions and will help the person identify and maintain a functional sense of self in the face of trauma 3Clinician will address the subjective and interpersonal sustaining factors of the illness. Encourage acutely traumatized persons to first rely on their inherent strengths, their existing support networks, and their own judgment may also reduce the need for further intervention 3. Early supportive interventions, psychoeducation, and case management appear to be helpful in acutely traumatized individuals, because these approaches promote engagement in ongoing care and may facilitate entry into evidence-based psychotherapeutic and psychopharmacological treatments. Enhance medication adherence by emphasizing to the patient fl when and how often to take the medicine, fl the expected time interval before beneficial effects of treatment may be noticed, fl the necessity to take medication even after feeling better, fl the need to consult with the physician before discontinuing medication, and fl steps to take if problems or questions arise 10. Increase understanding of, and adaptation to, the psychosocial effects of the disorder 11. Cognitive-behavioral psychotherapy strategies may be specifically helpful in reducing distress and high medical use. A strong relationship between the patient and the primary care physician can assist in longterm management. Psychosocial interventions that focus on maintaining social and occupational function despite chronic medical symptoms may be helpful. Recent studies have shown that cognitive-behavioral therapy reduces depressive symptoms in people with somatic diseases and should be used by clinician if symptoms of depression are present. Psychoeducation can be helpful by letting the patient know that physical symptoms may be exacerbated by anxiety or other emotional problems. However, be careful because patients are likely to resist suggestions that their condition is due to emotional rather than physical problems. The primary care physician should inform the patient that the symptoms do not appear to be due to a life-threatening, disabling, medical condition and should schedule regular visits for reassessment and reinforcement of the lacking severity of ongoing symptoms. The patient also may be told that some patients with similar symptoms have had spontaneous improvement, implying that spontaneous improvement may occur. Clinician will encourage patients to remain active and limit the effect of target symptoms on the quality of life and daily functioning. Clinician will encourage family members not to become preoccupied with the patients physical symptoms or medical care. Family members should direct the patient to report symptoms to their primary care physician. Clinician will establish a regular schedule for monitoring weight during treatment. Working between Sessions will be used by clinician to offer the patient the opportunity to experiment with changes in the context of a supportive therapeutic environment 7. Therapist is encouraged to explicitly acknowledge the difficulties of making real changes in one’s life and remind them not to “attach surplus meaning to resistance. Clinician will aim at preventing Weight Loss after Minimum Target Weight Has Been Achieved 5. Case summary: Ask your patient to write her own case summary, highlighting what was especially useful, what was difficult, etc. Risks for relapse: Ask your patient to write about the risks that she sees on the horizon. In that regard it is also useful to have her identify cues that will tell her she is off course or at risk for relapsing and have her prepare a plan for how to minimize or avert such risk. Goal Setting: Patients can prepare a list of goals for the coming month, 3 months, 1 year. As she reflects on the life she imagines, how does she want to be remembered (by the therapist, friends, or family)fl Ask your patient to write about past relapses and to be as detailed as possible about the patterns that were central to relapsing; discuss with her how she can handle things differently this time. Find out how the patient is using these instruments at the end of treatment and discuss how she can maximize their utility for transitioning out of treatment. Role playing: Use this technique to anticipate and work through any anticipated difficult situations. Address low self-esteem Information about the disorder: the cognitive-behavioral theory proposes that binge eating is largely a product of these patients’ distinctive form of dietary restraint (attempts to restrict their eating), which may or may not be accompanied by actual dietary restriction (true undereating in a physiological sense). Additional mechanisms (mood intolerance, clinical perfectionism, core low self-esteem, and major interpersonal difficulties) may also be maintaining the maladaptive behavior. Provide education, and to introduce two important procedures, “weekly weighing” and “regular eating. The overevaluation of shape and weight and its various expressions including body-checking and avoidance b. Clinical perfectionism, core low self-esteem, and major interpersonal difficulties Stage 4: (1) Ensure that the changes made in treatment are maintained over the following months, and (2) Minimize the risk of relapse in the long term. Consolidating gains made during treatment and preparing patients for future work on their own. An assignment of the “sick role” serves several functions, including granting the patient the permission to recover, delineating recovery as a responsibility of the patient, and allowing the patient to be relieved of other responsibilities in order to recover 2. Improvement of insomnia-related daytime impairments such as improvement of energy, attention or memory difficulties, cognitive dysfunction, fatigue, or somatic symptoms. Improvement in sleep related psychological distress Note: Rule out other mental disorders, general medical conditions, and drug abuse. Information about the disorder: Psychological and Behavioral Therapies: Psychological and behavioral interventions are effective and recommended in the treatment of chronic primary and comorbid (secondary) insomnia. Multicomponent therapy (without cognitive therapy) is effective and recommended therapy in the treatment of chronic insomnia. Other common therapies include sleep restriction, paradoxical intention, and biofeedback therapy. Although all patients with chronic insomnia should adhere to rules of good sleep hygiene, there is insufficient evidence to indicate that sleep hygiene alone is effective in the treatment of chronic insomnia. Older approved drugs for insomnia including barbiturates, barbiturate-type drugs and chloral hydrate are not recommended for the treatment of insomnia. The following guidelines apply to prescription of all medications for management of chronic insomnia: • Pharmacological treatment should be accompanied by patient education regarding: (1) treatment goals and expectations; (2) safety concerns; (3) potential side effects and drug interactions; (4) other treatment modalities (cognitive and behavioral treatments); (5) potential for dosage escalation; (6) rebound insomnia. Whenever possible, patients should receive an adequate trial of cognitive behavioral treatment during long-term pharmacotherapy. Long-term prescribing should be accompanied by consistent follow-up, ongoing assessment of effectiveness, monitoring for adverse effects, and evaluation for new onset or exacerbation of existing comorbid disorders Long-term administration may be nightly, intermittent. Stimulus control is designed to extinguish the negative association between the bed and undesirable outcomes such as wakefulness, frustration, and worry. These negative states are frequently conditioned in response to efforts to sleep as a result of prolonged periods of time in bed awake. The objectives of stimulus control therapy are for the patient to form a positive and clear association between the bed and sleep and to establish a stable sleep-wake schedule. Instructions: Go to bed only when sleepy; maintain a regular schedule; avoid naps; use the bed only for sleep; if unable to fall asleep (or back to sleep) within 20 minutes, remove yourself from bed—engage in relaxing activity until drowsy then return to bed—repeat this as necessary. Patients should be advised to leave the bed after they have perceived not to sleep within approximately 20 minutes, rather than actual clock-watching which should be avoided. Relaxation training such as progressive muscle relaxation, guided imagery, or abdominal breathing, is designed to lower somatic and cognitive arousal states which interfere with sleep. Cognitive therapy uses a psychotherapeutic method to reconstruct cognitive pathways with positive and appropriate concepts about sleep and its effects. Common cognitive distortions that are identified and addressed in the course of treatment include: “I can’t sleep without medication,” “I have a chemical imbalance,” “If I can’t sleep I should stay in bed and rest,” “My life will be ruined if I can’t sleep. Multicomponent therapy [without cognitive therapy] utilizes various combinations of behavioral (stimulus control, relaxation, sleep restriction) therapies, and sleep hygiene education. Sleep restriction initially limits the time in bed to the total sleep time, as derived from baseline sleep logs. As sleep drive increases and the window of opportunity for sleep remains restricted with daytime napping prohibited, sleep becomes more consolidated.

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Early talks on the foundation of the SGA. The meeting was held in Professor Amstutz's office at the University of Heidelberg on 19./20. June 1965. Sitting (from left) A. Maucher, Lombard, P. Routhier, P. Ramdohr, G.L. Krol; standing: A. Bernard and C. Amstutz.